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Dosis de hidroclorotiazida 100 mg /m 2 daily for 4 weeks in patients with hyperaldosteronism, compared 2.75 mg/m 2 daily for weeks in an active placebo group. The incidence rate ratio was 1.22 (95% CI, 1.03-1.53), with no serious adverse events among patients treated with 10 mg/m 2 of hidroclorotiamine and no dose adjustment for renal function, as required in the active placebo group. group, Prescription drug use in canada 11% discontinued due to worsening of urinary symptoms, including 8% patients with severe dysuria and 1% renal insufficiency. In the subgroup of patients with mild degrees hyperaldosteronism treated 2.75 mg/m 2 of hidrocloromitin, there was no change in the incidence rate ratio and one patient was discontinued for treatment-related treatment-emergent hyperaldosteronism, an uncommon event of no importance in the clinical setting. In patients with severe degrees of hyperaldosteronism, the efficacy therapy was not influenced by concomitant use of any three beta-blockers (clopidogrel 0.4 mg daily plus atorvastatin 20 daily, rosuvastatin 40 mg or selegiline 20 daily), three diuretics (bromocriptine or pheniradine), six anticonvulsants (ketorolac 10 mg daily, valproate 2.5 mcg or sodium metabisulfite 0.5-1.0 mg daily), ten calcium channel blockers (lidocaine 50mg daily, chlorpromazine 100 mg every other day plus diltiazem 1-2 g daily), or an electrolyte imbalances. In conclusion, safety, efficacy, effectiveness, and tolerability of the use hidroclorotiamine 30 mg daily in children have been demonstrated. Based on the small number of observed adverse reactions, the frequency of serious events in this study is acceptable, but the possibility of clinically significant worsening symptoms and/or serious renal insufficiency should be carefully considered in these patients. The possibility some patients of development adverse changes in blood coagulation after prolonged treatment should be examined using routine monitoring. The FDA informed of a safety concern with thiazide-type medications. They should be evaluated on a case-by-case basis. The clinical trial was terminated early because of the occurrence adverse reaction and a possible association between this outcome and the medication. The results of trial are to be reported in a subsequent issue of the American Journal Hypertension. The study was supported by National Health and Medical Research Council of Singapore. The authors have nothing to disclose. Medscape General Editor: James V. Alpers is a physician and scientific editor of Medscape General. Disclaimer: The contents of this publication are solely the responsibility of authors and do not necessarily represent the official views of Centers for Disease Control and Prevention. This article was published by Medscape (September 2010) under the Creative Commons Attribution-NonCommercial 4.0 International license. See Editorial Note: Publication of this article is intended to provide a brief summary of the findings this report. full text of the study is available at: http://www.ncbi.nlm.nih.gov/pubmed/20357895. Please see the article on page 208536 in the journal for additional information regarding the editorial process and for updated patient information contact information. Disclosure Summary: The authors report no relevant financial relationships. Additional Contributions: We thank Mihai Ciocan for his statistical consultation and research assistance. The authors thank staff from Paediatric Endocrinology Unit of the Singapore Hospital for their helpful assistance in the interpretation of data. Potential Financial Conflicts of Interest: None reported.
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