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Amlodipine and fast heart rate variability as secondary outcomes at baseline (primary outcome measure), 6 mo (secondary 3 y (thirdary outcome measure), and 3 y again after a washout period (washout, control; Figure 3A). The primary outcome is effect of IPI on blood pressure, heart rate, respiratory rate (ROS) (p = 0.005), blood glucose 0.002), total cholesterol (LDL) (p = 0.002), and triglycerides (TG) (p = 0.001); the secondary outcomes are effect of IPI on blood pressure and pressure-related outcomes, R2 (p = 0.009), blood glucose and TG (p = 0.01), blood glucose-related (GGI) (p = 0.03) and other (r2 0.02) outcomes. FIGURE atorvastatin ratiopharm 20 mg filmtabletten 3 View largeDownload slide Heart rate variability and blood pressure (BP) change for all subjects in a randomized, double-blind, crossover study comparing IPI with a placebo at 6 mo in a patient with stable CHD following acute coronary syndromes. After 24 wk of treatment, BP remained within the normal range (baseline), then an 8-cm increase across blood pressure points was observed in subjects receiving IPI (mean change: −0.43 ± 0.07, p = 0.004; Figure 3B). Heart rate variability significantly increased by 1.6 ± 0.8 beats/min with IPI (mean change: 3.0 ± 1.6, p = 0.003). Heart rate variability also significantly increased over the 12-mo period with IPI (mean change: 4.8 ± 2.4 beats/min, n = 16 subjects) and decreased over that same period with a placebo (mean change: −3.0 ± 1.4 beats/min; n = 16 subjects). Atorva 180 Capsules 15mg $420 - $2.33 Per pill This decrease in heart rate variability was noted even in subjects who were receiving an exercise medication. (A) Six-month (blue) and 3-y (red) changes in diastolic blood pressure (BP) from baseline for subjects administered IPI. (B) Mean (±SEM) BP change from baseline for subject with the highest heart rate variability after IPI compared with placebo (top right triangle and bottom left triangle). Data was analyzed by linear mixed model and paired t test. FIGURE 3 View largeDownload slide Heart rate variability and blood pressure (BP) change for all subjects in a randomized, double-blind, crossover study comparing IPI with a placebo at 6 mo in a patient with stable CHD following acute coronary syndromes. After 24 wk of treatment, BP remained within the normal range (baseline), then an 8-cm increase across blood pressure points was observed in subjects receiving IPI (mean change: −0.43 ± 0.07, p = 0.004; Figure 3B). Heart rate variability significantly increased by 1.6 ± 0.8 beats/min with IPI (mean change: 3.0 ± 1.6, p = 0.003). Heart rate variability also significantly increased over the 12-mo period with IPI (mean change: 4.8 ± 2.4 beats/min, n = 16 subjects) and decreased over that same period buy atorvastatin 20 mg uk with a placebo (mean change: −3.0 ± 1.4 beats/min; n = 16 subjects). This decrease in heart rate variability was noted even in subjects who were receiving an exercise medication. ()
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